A new study has revealed that the pill used to stop the birth of a baby has 99.99 percent effectiveness in the prevention of pregnancies in rodents. However, don’t anticipate that a human-friendly version of the pill will be forthcoming shortly.
A fascinating new study on animals offers a unique opportunity to find a male-specific method of contraception.
Contraceptives target a specific protein found in our body, vitamin A, which helps create fertile Sperm and fertility. Researchers have administered this substance, YCT529, to male rodents, and mice showed significantly less Sperm for four weeks. After about four to six weeks, they stopped receiving the contraceptive mice and were able to infect a female mouse.
Since the early 1970s, researchers have been looking at ways to create men’s birth control pills specifically for the male population. While their findings enthuse the group behind this study, others are skeptical and believe that it’s simply an intriguing development that may not be available to the public. Experts say we shouldn’t anticipate the widespread availability of contraceptives for males.
“These are novel compounds,” explained. “These are new chemical compounds,” stated Professor. Christina Wang is an expert in contraceptives at The Lundquist Institute of Harbor-UCLA Medical Center. “You do not know what they can do until you study toxicology. ” The researchers have performed toxicology tests on mice, but a study conducted by Dr. Wang stressed that human studies are needed to establish the effectiveness of the medication.
Gunda Georg, an Associate Professor of Medical Chemistry at the University of Minnesota who led the study, highlighted differences between this research and other efforts to create a suitable contraceptive pill for men. “They consume food and drink and are sexually active, even if they do not have the Sperm. “
The treatment could be placed into clinical trials this year, the doctor. Georg stated. However, it could be a beginning step towards a longer-term plan despite the rapid time frame.
What have researchers studied other ways of contraceptives geared towards males?
This Minnesota research is among the latest in an ongoing series of research studies that seek to find the male form of the pill to prevent female births.
The National Institutes of Health conducts a clinical trial to assess a contraceptive formula known as NES/T. People apply the gel to their upper and lower arms and shoulders daily. The gel contains hormones and is currently being evaluated in clinical trials in phase II, according to the doctor of Dr. Wang, who is one of the leading research team members. She believes that If she’s hopeful, the gel could be ready within five years, but even that’s quite fast, in her opinion.
Contra line is a biotechnology firm situated in Virginia awaiting clinical trials for Adam, an injectable gel available for one calendar year. The company declares Adam to be ” the I.U.D., for men. “
Researchers in India are experimenting with the non-surgical vasectomy method known in this case as the Reversible Imperative of Sperm Under Guidance, commonly referred to informally as R.I.S.U.G., which involves injecting a gel into penis tubes that hold the Sperm. However, until these efforts undergo thorough study – and most importantly, tests on humans-a, a male-specific version of birth control similar to pills.
What are alternatives to birth control offered to men today?
Two male types of birth control: condoms and vasectomies.
Vasectomies can be reversed. However, the doctor will advise. Najari has said that he will not recommend an operation in the hopes of reversed surgery in the future. It is suggested to follow the American Urological Association vasectomy guidelines specify that reversals may not always be successful. He believes setbacks are generally longer than initial vasectomy and have longer recovery times, and insurance will not always cover the cost. Vasectomies are associated with complications, such as infections and chronic and acute discomfort.
Condoms also benefit from preventing sexually transmitted illnesses; however, condoms have the disadvantage of being “relatively unpopular,” Dr. Najari said. When people opt to use condoms, they can be damaged or torn, and they are also susceptible to damage and tear; and centers for Disease Control and Prevention estimate that the rate of failure is around 13 percent.
Why didn’t we have an effective pill to control births that worked for guys earlier?
The 1990s saw the World Health Organization conduct research into testosterone in the early 1990s as a contraceptive strategy and found that it was very effective in reducing the number of Sperm cells. However, high testosterone levels were required to inhibit the production of Sperm, which led to unpleasant adverse side effects such as acne caused by weight growth and mood swings.
These are the identical side adverse effects women suffer due to hormonal birth drugs. Birth medication for women to manage their pregnancy has been linked to blood clots.
However, certain studies regarding men’s birth control have resulted in highly negative adverse unwanted side results. In 2012 scientists put an end to an investigation of progestogen and testosterone because people complained of extreme acne, depression and pain after injecting.
Herati. Women have regular ovulation cycles, and males produce high levels of Sperm every day; he explained how this could make hormonal changes more difficult.
When can we anticipate seeing a male birth control program for males?
“There’s so much riding on this — the research and the social change that comes with it,” said Heather Vahdat, the Male Contraceptive Initiative executive director. This non-profit organization funded this Minnesota investigation. However, she believes that it will need 10 years at minimum for males to get to the market.
Although the drug proved to be highly effective in mice, these results might not translate to success for humans.
As per Georg, YCT529 will start testing on humans in clinical trials within the 3rd or 4th quarter of 2022. Researchers are altering the compound they have developed and testing the new structures to find these new-generation compounds. They hope that their research can finally bring the elusive oral contraceptive for men to the market.